CTCAE v4.0

Functionality & Mechanism This tool, developed by The Center for Biomedical Informatics at The Children's Hospital of Philadelphia, digitizes the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) v4.0. The interface provides hierarchical navigation through all 26 adverse event categories, facilitating access to standardized definitions and grading criteria (Grades 1-5). The system integrates a search function querying event names and definitions, and incorporates a bookmarking feature to expedite access to frequently referenced events for bedside clinical use.

Evidence & Research Context

• The application directly translates the NCI's CTCAE v4.0, a standard terminology system for adverse event reporting in clinical trials and oncology practice.
• The app's design objective is to convert the comprehensive source document into an intuitive, searchable mobile format for point-of-care reference.
• Associated research literature describes mobile reference applications as a mechanism for healthcare providers to obtain critical clinical information with greater efficiency.

Intended Use & Scope This application is designed for oncologists, clinical researchers, and other healthcare providers for the standardized grading of adverse events at the point of care. Its primary utility is as a rapid reference tool to ensure consistent application of NCI CTCAE criteria. The tool does not provide treatment guidance or replace professional clinical judgment.