Flockhart CYP450 Table

Functionality & Mechanism The Flockhart CYP450 Table is a specialized clinical reference tool from Indiana University that catalogs drug interactions mediated by the cytochrome P450 system. The interface organizes therapeutic agents according to their relationship with specific CYP isoforms, classifying them as substrates, inhibitors, or inducers. The system is designed for rapid reference, allowing clinicians and researchers to access classifications derived from published evidence. The platform facilitates the identification of potential pharmacologic interactions based on established metabolic pathways.

Evidence & Research Context

• The associated research establishes the table as a foundational teaching and reference tool for healthcare providers and researchers investigating CYP-mediated drug interactions.
• The system's classifications are grounded in published scientific literature demonstrating that a specific CYP isoform contributes to a drug's metabolism.
• Research contextualizing the table highlights the clinical importance of understanding CYP substrates, inhibitors, and inducers for managing drug interactions in specialized fields.
• The authors explicitly note that a drug's inclusion does not necessarily signify that a listed isoform is its principal metabolic pathway in vivo.

Intended Use & Scope This tool is intended for physicians, pharmacists, nurses, and researchers as a focused educational and reference guide. Its primary utility is the identification of potential drug-drug interactions involving the CYP450 system. The table does not include interactions mediated by other enzymes (e.g., UGTs) or drug transporters. Clinical decisions require professional judgment and consultation of comprehensive pharmacologic resources.