PharMe

Functionality & Mechanism

Developed by the Mount Sinai Health System, the PharMe application provides patients with direct access to personal pharmacogenomic test results. The system securely loads laboratory data and presents personalized, annotated therapeutic guidance derived from CPIC and FDA guidelines, covering 159 medications across 17 genes. The interface facilitates exploration of gene-based drug responses, incorporates phenoconversion data for refined interpretations, and allows for the generation of exportable reports to support clinical consultations.

Evidence & Research Context

• An initial evaluation study assessed the application's design and usability in a remote pilot with a small cohort of digitally literate participants.
• The system demonstrated high usability, achieving a mean System Usability Scale (SUS) score of 82.86, which indicates an excellent user experience.
• Participants in the pilot successfully completed the majority of assigned tasks, yielding an average user satisfaction rating of 4.1 out of 5 stars.
• A larger clinical validation study is underway to assess the system in a more diverse patient population.

Intended Use & Scope

PharMe is designed for patient participants within approved research studies to review and understand their personal pharmacogenomic results. Its primary utility is as an informational and educational tool to support clinician-patient dialogue. The application does not provide medical advice or replace professional clinical judgment; all therapeutic decisions require consultation with a qualified healthcare provider.