SafeLocal

Functionality & Mechanism

Developed at the Johns Hopkins University School of Medicine, SafeLocal is a clinical calculator designed to determine maximum safe dosages for local anesthetics. The interface captures patient-specific variables, including weight, relevant comorbidities (e.g., renal or hepatic dysfunction), and the presence of additives like epinephrine. It processes single agents or complex mixtures to calculate the maximum dose and tracks the remaining volume available for safe administration, mitigating the risk of local anesthetic systemic toxicity (LAST).

Evidence & Research Context

• Core dosage calculations are derived from established anesthetic principles outlined in the clinical reference text Miller's Anesthesia.
• Adjustments for patient comorbidities, such as severe renal dysfunction or advanced heart failure, are based on the multifactorial model for local anesthetic dosing.
• The app's safety framework is adapted from the American Society of Regional Anesthesia and Pain Medicine (ASRA) Checklist for Managing Local Anesthetic Systemic Toxicity.

Intended Use & Scope

This clinical reference tool is intended for anesthesiologists, surgeons, and other qualified medical providers. Its primary utility is as a point-of-care decision-support aid for calculating local anesthetic dosages. The tool provides recommendations based on established guidelines but does not replace independent clinical judgment, which is required for all patient care decisions.