SOS/VOD Diagnosis and Grading

Functionality & Mechanism This clinical reference tool operationalizes established diagnostic and grading criteria for Sinusoidal Obstructive Syndrome (SOS)/Veno-Occlusive Disease (VOD). The interface guides clinicians through a structured assessment, capturing key patient parameters necessary to apply guidelines such as the pediatric European Society for Blood and Marrow Transplantation (pEBMT) criteria. The system facilitates rapid classification of SOS/VOD severity, supporting timely and evidence-based clinical decision-making for pediatric, adolescent, and young adult (Pedi-AYA) patients post-transplantation or chemotherapy.

Evidence & Research Context The diagnostic framework integrated into the app is supported by clinical research demonstrating its potential utility for early detection.

• A multi-center retrospective cohort study (N=488) of pediatric hematopoietic cell transplantation patients found pEBMT criteria identified a significantly higher incidence of SOS/VOD (21.5%) compared to older criteria.
• Application of the pEBMT criteria facilitated the identification of 44 patients who would have otherwise been missed by historical diagnostic standards used in the cohort.
• Among diagnosed patients, 70.5% developed very severe disease, and the diagnosis was associated with significantly lower overall survival, underscoring the need for early detection.
• The research concludes that pEBMT criteria enable more sensitive and prompter diagnosis, and their universal adoption may improve patient outcomes.

Intended Use & Scope This tool is intended for use by hematologists, oncologists, and other healthcare professionals experienced in treating SOS/VOD. It functions as a clinical decision support resource to assist with the application of complex diagnostic criteria. The app does not provide a definitive diagnosis and is not a substitute for expert clinical judgment.