CRISPR Cutout

Functionality & Mechanism

CRISPR Cutout is an educational game developed by the Institute for Molecular Medicine and Infectious Disease at Drexel University College of Medicine. The app introduces complex genome editing concepts through interactive gameplay. It visualizes the CRISPR-Cas9 mechanism by tasking players with creating a guide RNA (gRNA) to identify a target DNA sequence. Users then direct the Cas9 enzyme to cut a segment of HIV DNA from a cell, simulating the gene-editing process and its potential applications.

Development & Context

• The game was created by a collaborative team of faculty and student interns at Drexel University's College of Medicine.
• It received a silver medal from the International Serious Play Awards, recognizing its design as a learning product.
• The news coverage highlights its development as the fourth educational game released by the Institute.
• Subject-matter experts in virology and immunology consulted on the project to support the scientific accuracy of the gameplay.

Intended Use & Scope

This game is designed as an educational tool for non-scientists, students, and patients aged 13 and older seeking to understand gene editing. It provides a conceptual introduction to CRISPR technology using HIV as an example. The app serves as a supplementary learning resource for science curricula, not as a clinical or diagnostic tool.